Physical quality test of jamblang fruit ethanol extract antioxidant cream (syzygium cumini (l.) Skeels)
Abstract
Background: Antioxidants are compounds that can protect against oxidative stress caused by free radicals, both from inside the body (endogenous) and outside (exogenous). Many plants have antioxidant properties, including gambling (Syzygium cumini (L.) Skeels). This plant is known to have various bioactive components that can capture and neutralize free radicals; Jamblang fruit has antioxidant activity caused by the content of flavonoid compounds in it. These compounds can be utilized as topical preparations for skin care products.
Objective: This study aims to determine the effect of ethanol extract concentration of jamblang fruit (Syzygium cumini (L.) Skeels) on the physical stability of the cream.
Methods: This research is conducted in an experimental laboratory. Jamblang fruit extract was obtained using the maceration method using 96% ethanol. The extract was then formulated in the form of a m/a type cream preparation with concentration variations of 1% (FI), 2% (F2), and 3% (F3). The physical stability test of the cream includes viscosity, spread, adhesion, and pH value tests. The data is analyzed to determine the effect of adding extracts and the storage time on the physical stability of the cream.
Results: The test showed that an increase in the concentration of ethanol extract from jamblang fruit led to a decrease in pH value, viscosity value, and adhesion and could increase dispersion. It was concluded that the variation in the concentration of ethanol extract from jamblang fruit influenced the physical properties of M/A cream.
Conclusion: It can be concluded that the variation in the concentration of ethanol extract of jamblang fruit affects the physical properties of the oil cream in water (M/A). The effects caused include a decrease in pH value, a reduction in viscosity, a decrease in adhesion, and an increase in dispersion. These changes will ultimately affect the physical stability of the cream preparation.
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References
Aini, H. Q., Tiadeka, P. and Naimah, J. (2024) ‘Formulation and Evaluation of Belt Leaf Extract Cream Preparation with Varied Concentrations Of 96% Ethanol as Anti-Septic’, PHARMADEMICA : Jurnal Kefarmasian dan Gizi, 3(2), pp. 63–71. doi: 10.54445/pharmademica.v3i2.46.
Akmal, T., Tanjung, Y. P. and Afrizki, Y. (2023) ‘Formulation of Blush on Cream from Roselle (Hibiscus sabdariffa L.) Flower Extract with Olive Oil as Emollients’, Indonesian Journal of Pharmaceutical Science and Technology, 10(2), pp. 111–118.
Alves, T. et al. (2021) ‘Complying with the Guideline for Quality and Equivalence for Topical Semisolid Products: The Case of Clotrimazole Cream’, Pharmaceutics, 13(4), p. 555. doi: 10.3390/pharmaceutics13040555.
Anggara, R. A. S. B., Fauziyah, A. and Ilmi, I. M. B. (2021) ‘Pengaruh Ekstrak Buah Jamblang Terhadap Kadar Antosianin, Aktivitas Antioksidan Dan Sifat Organoleptik Es Krim Ubi Ungu’, Ghidza: Jurnal Gizi dan Kesehatan, 5(1), pp. 95–106. doi: 10.22487/ghidza.v5i1.207.
Ariem, F., Yamlean, P. V. . and Lebang, J. S. (2020) ‘Formulasi dan uji efektivitas antioksidan sediaan krim ekstrak etanol daun belimbing wuluh (averrhoa bilimbi l. ) dengan menggunakan metode dpph (1,1-diphenyl-2-picrylhydrazyl)’, PHARMACON, 9(4), p. 501. doi: 10.35799/pha.9.2020.31355.
Chaudhary, P. et al. (2023) ‘Oxidative stress, free radicals and antioxidants: potential crosstalk in the pathophysiology of human diseases’, Frontiers in Chemistry, 11, p. 1158198. doi: 10.3389/fchem.2023.1158198.
Guo, C., Zhang, M. and Devahastin, S. (2021) ‘Color/aroma changes of 3D-Printed buckwheat dough with yellow flesh peach as triggered by microwave heating of gelatin-gum Arabic complex coacervates’, Food Hydrocolloids, 112, p. 106358. doi: 10.1016/j.foodhyd.2020.106358.
Hidayah, H. et al. (2022) ‘Literature Review: Potential of Jamblang (Syzygium Cumini (L.) Skeels) Plants as Nephroprotectors Based on Active Compound’, KESANS: International Journal of Health and Science, 2(2), pp. 73–79.
Latif, A. R., Sugihartini, N. and Guntarti, A. (2021) ‘Sifat Fisik Krim Tipe A/M Dengan Variasi Konsentrasi Ekstrak Etanol Daun Kelor (Moringa Oliefera) Menggunakan Emulgator Tween 80 Dan Span 80’, Media Farmasi, 16(1), p. 9. doi: 10.32382/mf.v16i1.1408.
Lubis, M. S. et al. (2023) ‘Test of sunscreen activity of pineapple weevil ethanol extract (ananas comosus (L.) merr.) in gel and lotion preparations’, AMCA Journal of Science and Technology, 3(1), pp. 7–12. doi: 10.51773/ajst.v3i1.196.
Lumentut, N., Edi, H. J. and Rumondor, E. M. (2020) ‘Formulasi dan Uji Stabilitas Fisik Sediaan Krim Ekstrak Etanol Kulit Buah Pisang Goroho (Musa acuminafe L.) Konsentrasi 12.5% Sebagai Tabir Surya’, Jurnal MIPA, 9(2), p. 42. doi: 10.35799/jmuo.9.2.2020.28248.
Mahindrakar, K. V and Rathod, V. K. (2020) ‘Ultrasonic assisted aqueous extraction of catechin and gallic acid from Syzygium cumini seed kernel and evaluation of total phenolic, flavonoid contents and antioxidant activity’, Chemical Engineering and Processing - Process Intensification, 149, p. 107841. doi: https://doi.org/10.1016/j.cep.2020.107841.
Mandal, S. K. et al. (2023) ‘Chapter 38 - Syzygium cumini (L.) Skeels.’, in Belwal, T., Bhatt, I., and Devkota, H. B. T.-H. F. and B. (eds). Academic Press, pp. 403–418. doi: https://doi.org/10.1016/B978-0-323-85591-4.00001-5.
do Nascimento-Silva, N. R. R., Bastos, R. P. and da Silva, F. A. (2022) ‘Jambolan (Syzygium cumini (L.) Skeels): A review on its nutrients, bioactive compounds and health benefits’, Journal of Food Composition and Analysis, 109, p. 104491. doi: 10.1016/j.jfca.2022.104491.
Putriana Rahman, A., . L. and H, S. (2022) ‘Antioxidant Face Cream Formulation of Ethanol Extract from Soursop leaves (Annona muricata L)’, Berkala Ilmiah Kimia Farmasi, 9(1), pp. 1–8. doi: 10.20473/bikfar.v9i1.40889.
Rahayu, P., Monica, E. and Yulinda Cesa, F. (2023) ‘Formulasi dan evaluasi sediaan krim pelembap dan antioksidan kombinasi ekstrak kulit buah manggis garcinia mangostana l dan lidah buaya aloe vera l’, Sainsbertek Jurnal Ilmiah Sains & Teknologi, 3(2), pp. 52–65. doi: 10.33479/sb.v3i2.234.
Rauf, A. et al. (2021) ‘Phytochemical composition, in vitro urease, α-glucosidase and phosphodiesterase inhibatroy potency of Syzygium cumini (Jamun) fruits’, South African Journal of Botany, 143, pp. 418–421. doi: 10.1016/j.sajb.2021.04.006.
Setyawati, E., Nurasmi, N. and Irnawati, I. (2021) ‘Studi Analisis Zat Gizi Biskuit Fungsional Subtitusi Tepung Kelor dan Tepung Ikan Gabus’, Jurnal Ilmiah Kesehatan Sandi Husada, 10(1), pp. 94–104. doi: 10.35816/jiskh.v10i1.516.
Thevamirtha, C. et al. (2023) ‘An Insight into the antioxidant activity of the facial cream, solid soap and liquid soap made using the carotenoid extract of palmyrah (Borassus flabellifer) fruit pulp’, Industrial Crops and Products, 195, p. 116413. doi: 10.1016/j.indcrop.2023.116413.
Tungadi, R., Sy. Pakaya, M. and D.as’ali, P. W. (2023) ‘Formulasi dan Evaluasi Stabilitas Fisik Sediaan Krim Senyawa Astaxanthin’, Indonesian Journal of Pharmaceutical Education, 3(1), pp. 117–124. doi: 10.37311/ijpe.v3i1.14612.
Widyastuti, W. and Hilaliyati, N. (2021) ‘Potensi Ekstrak Buah Jambu Jamblang (Syzygium Cumini L.Skeel) Sebagai Antioksidan Dan Tabir Surya’, Jurnal Ilmiah Farmasi Farmasyifa, 4(1), pp. 112–119. doi: 10.29313/jiff.v4i1.6716.
Witanti, L. and Endriyatno, N. C. (2024) ‘Formulasi Dan Uji Fisik Krim Ekstrak Herba Meniran (Pyllanthus Niruri L.) Dengan Variasi Asam Stearat Dan Trietanolamin’, Jurnal Penelitian Farmasi Indonesia, 13(1), pp. 23–31. doi: 10.51887/jpfi.v13i1.1854.
Yuliana, T. P. et al. (2023) ‘Formulasi Sediaan Krim Ekstrak Etanol Kulit Buah Semangka Merah Sebagai Krim Antijerawat’, Journal Syifa Sciences and Clinical Research, 5(2), pp. 261–274. doi: 10.37311/jsscr.v5i2.19590.
Zam Zam, A. N. and Musdalifah, M. (2022) ‘Formulasi dan Evaluasi Kestabilan Fisik Krim Ekstrak Biji Lada Hitam (Piper nigrum L.) Menggunakan Variasi Emulgator’, Journal Syifa Sciences and Clinical Research, 4(2), pp. 304–313. doi: 10.37311/jsscr.v4i2.14146.
Zhang, E. et al. (2021) ‘Biodegradable Zwitterionic Cream Gel for Effective Prevention of Postoperative Adhesion’, Advanced Functional Materials, 31(10), p. 2009431. doi: 10.1002/adfm.202009431.